The role of VEGF-A165 b in trophoblast survival

Doc number: 278 Abstract Background: Pre-eclampsia remains a dominant cause of maternal and fetal mortality in developed countries. In a previous prospective study we identified a fall in the VEGF-A isoform VEGF-A165 b in the plasma of patients in the first trimester to be a predictor of later pre-e...

Full description

Saved in:
Bibliographic Details
Published in:BMC pregnancy and childbirth 2014-01, Vol.14
Main Authors: Bills, Victoria L, Hamdollah-Zadeh, Maryam, Soothill, Peter W, Harper, Steven J, Bates, David O
Format: Article
Language:English
Subjects:
Colleges & universities
Cytotoxicity
Dehydrogenases
Experiments
Hypoxia
Placenta
Preeclampsia
Pregnancy
Rodents
Variance analysis
Vascular endothelial growth factor
Veins & arteries
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Doc number: 278 Abstract Background: Pre-eclampsia remains a dominant cause of maternal and fetal mortality in developed countries. In a previous prospective study we identified a fall in the VEGF-A isoform VEGF-A165 b in the plasma of patients in the first trimester to be a predictor of later pre-eclampsia. VEGF-A165 b has been shown to have potent cytoprotective properties in many cell types. We therefore tested the hypothesis that VEGF-A165 b may be cytoprotective for placental trophoblasts. Methods: We used an immortalised first trimester trophoblast cell line exposed to chemical toxicity, and physiological (
ISSN:1471-2393
DOI:10.1186/1471-2393-14-278