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Other differences exist between murine and human DCs, and as pointed out in their letter, DCs from various compartments respond to activation in different fashions. [...]the activation of the human monocyte-derived DCs by LPS itself decreased Jagged-1 expression, whereas in the TH2 allergen-driven s...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2013-04, Vol.131 (4), p.1257
Main Authors: Massoud, Amir H, Kaufman, Gabriel N, Mourad, M Walid, Piccirillo, Ciriaco, Mazer, Bruce D
Format: Article
Language:English
Subjects:
Allergies
Ligands
Medical research
Rodents
Online Access:Get full text
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Summary:Other differences exist between murine and human DCs, and as pointed out in their letter, DCs from various compartments respond to activation in different fashions. [...]the activation of the human monocyte-derived DCs by LPS itself decreased Jagged-1 expression, whereas in the TH2 allergen-driven system Jagged-1 was clearly increased from baseline, and reversed by IVIg. Recent work from our laboratory on murine bone-marrow-derived DCs confirms the observation that preincubation with OVA induces a Notch-ligand phenotype consistent with in vivo antigen exposure, which is reversible by IVIg (Fig 1). [...]comparing the effect of IVIg in a TH2-antigen-driven system with the TH1-polarizing activation via LPS may lead to divergent conclusions.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2013.01.032