Phenotypic differences between IgG4+and IgG1+B cells point to distinct regulation of the IgG4response

Furthermore, there was a higher expression of the Fc[straight epsilon] receptor (CD23) on IgG4+ cells (Fig 2, B). Because many allergens are good inducers of IgG4 as well as IgE and CD23 can be upregulated by IL-4,8 it is interesting that IgG4+ B cells appear to have increased capacity to capture Ig...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2014-01, Vol.133 (1), p.267
Main Authors: Lighaam, Laura C, Vermeulen, Ellen, den Bleker, Tamara, Meijlink, Kimberley J, Aalberse, Rob C, Barnes, Eleanor, Culver, Emma L, van Ham, S Marieke, Rispens, Theo
Format: Article
Language:English
Subjects:
Antigens
Cytokines
Gene expression
Immune system
Immunoglobulins
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Summary:Furthermore, there was a higher expression of the Fc[straight epsilon] receptor (CD23) on IgG4+ cells (Fig 2, B). Because many allergens are good inducers of IgG4 as well as IgE and CD23 can be upregulated by IL-4,8 it is interesting that IgG4+ B cells appear to have increased capacity to capture IgE molecules. Signaling via IgE might trigger IgG4+ cells and contribute to dampening of allergic IgE responses. Besides IgE antibodies, CD23 binds to CD21 and several integrins.8 Taken together, IgG4+ B cells may stand out in the way they receive signals via the B-cell receptor complex.\n5) containing 0.003% (v/v) H2O2.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2013.07.044