Effect of delayed anthrax vaccine dose onBacillus anthracisprotective antigen IgG response and lethal toxin neutralization activity

We describe theBacillus anthracisprotective antigen IgG antibody response and theB. anthracislethal toxin neutralization activity to a delayed dose of anthrax vaccine adsorbed (AVA, BioThrax®) using validated assays. 373 individuals received 1, 2, or 3 priming doses, 18-24 months afterward, they rec...

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Bibliographic Details
Published in:Vaccine 2013-10, Vol.31 (44), p.5009
Main Authors: Pittman, Phillip R, Fisher, Diana, Quinn, Xiaofei, Schmader, Trevor, Barrera-Oro, Julio G
Format: Article
Language:English
Subjects:
Anthrax
Antigens
Disease
Neutralization
Response rates
Toxins
Vaccines
Variance analysis
Online Access:Get full text
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Summary:We describe theBacillus anthracisprotective antigen IgG antibody response and theB. anthracislethal toxin neutralization activity to a delayed dose of anthrax vaccine adsorbed (AVA, BioThrax®) using validated assays. 373 individuals received 1, 2, or 3 priming doses, 18-24 months afterward, they received a delayed dose of AVA. Overall, 23.6% of subjects showed detectable anti-PA IgG before the boost, compared to 99.2% (P
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.08.086