An Enantiodivergent Synthesis of (+)- and (−)-Centrolobines by Asymmetric Esterification Catalyzed by (R)-(+)-N-Methylbenzoguanidine ((R)-NMBG)

Seventh heaven: The enantiodivergent synthesis of (+)‐ and (−)‐centrolobines was achieved in a total of seven steps by using an asymmetric esterification in the presence of catalytic (R)‐(+)‐N‐methylbenzoguanidine as the key reaction.

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Bibliographic Details
Published in:Asian journal of organic chemistry 2013-11, Vol.2 (11), p.920-922
Main Authors: Nakata, Kenya, Tokumaru, Tatsuya, Iwamoto, Hidetoshi, Nishigaichi, Yutaka, Shiina, Isamu
Format: Article
Language:English
Subjects:
centrolobines
kinetic resolution
N-methylbenzoguanidine
natural products
Organic chemistry
organocatalysis
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Description
Summary:Seventh heaven: The enantiodivergent synthesis of (+)‐ and (−)‐centrolobines was achieved in a total of seven steps by using an asymmetric esterification in the presence of catalytic (R)‐(+)‐N‐methylbenzoguanidine as the key reaction.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.201300139