Matrix Metalloproteinases are Involved in Cardiovascular Diseases

This MiniReview describes the essential biochemical and molecular aspects of matrix metalloproteinases (MMPs) and briefly discusses how they engage in different diseases, with particular emphasis on cardiovascular diseases. There is compelling scientific evidence that many MMPs, especially MMP‐2, pl...

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Bibliographic Details
Published in:Basic & clinical pharmacology & toxicology 2014-10, Vol.115 (4), p.301-314
Main Authors: Azevedo, Aline, Prado, Alejandro F., Antonio, Raquel C., Issa, Joao P., Gerlach, Raquel F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - enzymology
Cardiovascular Diseases - pathology
Disease Models, Animal
Enzymes
Humans
Matrix Metalloproteinase Inhibitors - therapeutic use
Matrix Metalloproteinases - metabolism
Medical research
Medical sciences
Pharmacology. Drug treatments
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Summary:This MiniReview describes the essential biochemical and molecular aspects of matrix metalloproteinases (MMPs) and briefly discusses how they engage in different diseases, with particular emphasis on cardiovascular diseases. There is compelling scientific evidence that many MMPs, especially MMP‐2, play important roles in the development of cardiovascular diseases; inhibition of these enzymes is beneficial to many cardiovascular conditions, sometimes precluding or postponing end‐organ damage and fatal outcomes. Conducting comprehensive discussions and further studies on how MMPs participate in cardiovascular diseases is important, because inhibition of these enzymes may be an alternative or an adjuvant for current cardiovascular disease therapy.
ISSN:1742-7835
1742-7843
DOI:10.1111/bcpt.12282