The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal

Introduction Many environmental and dietary influences can cause immune cells to produce biological mediators that increase airway inflammation. A high-fat meal (HFM) is one stimulus that increases airway inflammation in healthy individuals. Supplementation with omega-3 fatty acids can reduce inflam...

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Bibliographic Details
Published in:European journal of applied physiology 2014-04, Vol.114 (4), p.675-682
Main Authors: Ade, Carl J., Rosenkranz, S. K., Harms, C. A.
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Asthma
Biomedical and Life Sciences
Biomedicine
Diet
Dietary Fats - administration & dosage
Dietary Fats - adverse effects
Dietary Supplements
Fatty acids
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-3 - therapeutic use
Fish oils
Human Physiology
Humans
Inflammation - etiology
Inflammation - metabolism
Inflammation - prevention & control
Male
Meals
Nitric Oxide - metabolism
Nutrition research
Occupational Medicine/Industrial Medicine
Original Article
Physiology
Respiratory Physiological Phenomena - drug effects
Respiratory System - metabolism
Respiratory System - pathology
Single-Blind Method
Sports Medicine
Triglycerides
Triglycerides - blood
Young Adult
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Summary:Introduction Many environmental and dietary influences can cause immune cells to produce biological mediators that increase airway inflammation. A high-fat meal (HFM) is one stimulus that increases airway inflammation in healthy individuals. Supplementation with omega-3 fatty acids can reduce inflammation systemically and may be beneficial to the airways. Purpose To determine if omega-3 fatty acid supplementation via fish oil would mitigate the airway inflammatory response induced by a single HFM. Methods Seventeen non-asthmatic men (22 ± 2 years.) were supplemented with 3,000 mg × day −1 fish oil or a placebo for 3 weeks. Fractional exhaled nitric oxide (FE NO ; a marker of airway inflammation), impulse oscillometry (a measure of respiratory impedance), pulmonary function, and triglycerides were measured prior to and 2 h following a HFM. Results Following a HFM, triglycerides increased in both fish oil and placebo groups compared to pre-HFM (~59 and ~49 %, respectively, p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-013-2792-7