Limb-sparing management with surgical resection, external-beam and intraoperative electron-beam radiation therapy boost for patients with primary soft tissue sarcoma of the extremity: A multicentric pooled analysis of long-term outcomes

Background or purpose A joint analysis of data from three contributing centres within the intraoperative electron-beam radiation therapy (IOERT) Spanish program was performed to investigate the main contributions of IORT to the multidisciplinary treatment of high-risk extremity soft tissue sarcoma (...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2014-10, Vol.190 (10), p.891-898
Main Authors: Calvo, Felipe A., Sole, Claudio V., Polo, Alfredo, Cambeiro, Mauricio, Montero, Angel, Alvarez, Ana, Cuervo, Miguel, Julian, Mikel San, Martinez-Monge, Rafael
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Combined Modality Therapy - methods
Combined Modality Therapy - statistics & numerical data
Dose Fractionation, Radiation
Electrons - therapeutic use
Female
Humans
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Middle Aged
Minimally Invasive Surgical Procedures - mortality
Oncology
Organ Sparing Treatments - mortality
Original Article
Prevalence
Radiotherapy
Radiotherapy, Conformal - mortality
Radiotherapy, High-Energy - mortality
Retrospective Studies
Risk Factors
Sarcoma - mortality
Sarcoma - therapy
Spain - epidemiology
Survival Rate
Treatment Outcome
Young Adult
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Summary:Background or purpose A joint analysis of data from three contributing centres within the intraoperative electron-beam radiation therapy (IOERT) Spanish program was performed to investigate the main contributions of IORT to the multidisciplinary treatment of high-risk extremity soft tissue sarcoma (STS). Methods and materials Patients with an histologic diagnosis of primary extremity STS, with absence of distant metastases, undergoing limb-sparing surgery with radical intent, external beam radiotherapy (median dose 45 Gy) and IOERT (median dose 12.5 Gy) were considered eligible for participation in this study. Results From 1986–2012, a total of 159 patients were analysed in the study from three Spanish institutions. With a median follow-up time of 53 months (range 4–316 years), 5-year local control (LC) was 82 %. The 5-year IOERT in-field control, disease-free survival (DFS) and overall survival (OS) were 86, 62 and 72 %, respectively. On multivariate analysis, only microscopically involved margin (R1) resection status retained significance in relation to LC (HR 5.20, p  
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-014-0640-2