Target Antigens for Perinuclear Antineutrophil Cytoplasmic Antibodies in Iranian Patients with Ulcerative Colitis

Patients with ulcerative colitis (UC) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). The aim of the present study was to evaluate the target antigens for p-ANCA in Iranian patients with UC. p-ANCA target antigens including elastase, lactoferrin, cathepsin G,...

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Published in:Middle East journal of digestive diseases 2014-10, Vol.6 (4), p.172
Main Authors: Bahari, Ali, Aarabi, Mahmoud, Hedayati, Mehdi, Jarollahi, Ali, Firouzi, Farzad, Aghazadeh, Rahim, Zali, Mohammad Reza, Bari, Zohreh, Hashemi, Mohammad, Esmaeilzadeh, Abbas, Mokhtarifar, Ali, Ganji, Azita
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container_issue 4
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container_title Middle East journal of digestive diseases
container_volume 6
creator Bahari, Ali
Aarabi, Mahmoud
Hedayati, Mehdi
Jarollahi, Ali
Firouzi, Farzad
Aghazadeh, Rahim
Zali, Mohammad Reza
Bari, Zohreh
Hashemi, Mohammad
Esmaeilzadeh, Abbas
Mokhtarifar, Ali
Ganji, Azita
description Patients with ulcerative colitis (UC) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). The aim of the present study was to evaluate the target antigens for p-ANCA in Iranian patients with UC. p-ANCA target antigens including elastase, lactoferrin, cathepsin G, myeloproxidase, lysozyme, and bactericidal permeability increasing protein (BPI) were determined in 113 patients with UC using enzyme-linked immunosorbent assay. A total of 59.2% of the patients were positive for at least one antigen and p-ANCA directed against lactoferrin, elastase, lysozyme, cathepsin G, BPI, and myeloproxidase in 31.5%, 25.9%, 8.3%, 7.4%, 5.6%, and 0% of the patients, respectively.
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title Target Antigens for Perinuclear Antineutrophil Cytoplasmic Antibodies in Iranian Patients with Ulcerative Colitis
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