Traditional serrated adenoma has two pathways of neoplastic progression that are distinct from the sessile serrated pathway of colorectal carcinogenesis

Traditional serrated adenoma is one type of colorectal serrated neoplasm and a precursor of colorectal cancer. We evaluated the pathologic and molecular features of 60 traditional serrated adenomas with cytologic dysplasia and/or invasive carcinoma. On the basis of morphological features, 16 cases (...

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Bibliographic Details
Published in:Modern pathology 2014-10, Vol.27 (10), p.1375-1385
Main Authors: Tsai, Jia-Huei, Liau, Jau-Yu, Lin, Yu-Lin, Lin, Liang-In, Cheng, Yi-Chen, Cheng, Mei-Ling, Jeng, Yung-Ming
Format: Article
Language:English
Subjects:
692/420/755
692/699/67/1504/1885
692/700/139/422
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenoma - genetics
Adenoma - pathology
Aged
BRAF
Cell Transformation, Neoplastic - genetics
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
CpG island methylator phenotype
CpG Islands - genetics
Disease Progression
DNA Methylation
Female
Humans
Immunohistochemistry
KRAS
Laboratory Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Morphology
Mutation
original-article
Pathology
Polyps
Precancerous Conditions - genetics
Precancerous Conditions - pathology
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins p21(ras)
ras Proteins - genetics
Reverse Transcriptase Polymerase Chain Reaction
traditional serrated adenoma
Tumors
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Summary:Traditional serrated adenoma is one type of colorectal serrated neoplasm and a precursor of colorectal cancer. We evaluated the pathologic and molecular features of 60 traditional serrated adenomas with cytologic dysplasia and/or invasive carcinoma. On the basis of morphological features, 16 cases (27%) were categorized as traditional serrated adenoma with serrated dysplasia and 25 cases (42%) as traditional serrated adenoma with conventional adenomatous dysplasia. In addition, 19 cases (31%) showed an overall tubulovillous adenomatous structure but with focal serrated feature. Traditional serrated adenoma with serrated dysplasia had a significantly higher frequency of BRAF mutation than traditional serrated adenoma with conventional adenomatous dysplasia and tubulovillous adenoma with serrated feature (P=0.006), whereas traditional serrated adenoma with conventional adenomatous dysplasia and tubulovillous adenoma with serrated feature had higher frequencies of KRAS mutation than traditional serrated adenoma with serrated dysplasia (P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2014.35