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Short Antimicrobial Lipo-[alpha]/[gamma]-AA Hybrid Peptides

The last two decades have seen the rise of antimicrobial peptides (AMPs) to combat emerging antibiotic resistance. Herein we report the solid-phase synthesis of short lipidated [alpha]/[gamma]-AA hybrid peptides. This family of lipo-chimeric peptidomimetics displays potent and broad-spectrum antimic...

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Published in:Chembiochem : a European journal of chemical biology 2014-10, Vol.15 (15), p.2275
Main Authors: Li, Yaqiong, Smith, Christina, Wu, Haifan, Teng, Peng, Shi, Yan, Padhee, Shruti, Jones, Torey, Nguyen, Anh-My, Cao, Chuanhai, Yin, Hang, Cai, Jianfeng
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container_title Chembiochem : a European journal of chemical biology
container_volume 15
creator Li, Yaqiong
Smith, Christina
Wu, Haifan
Teng, Peng
Shi, Yan
Padhee, Shruti
Jones, Torey
Nguyen, Anh-My
Cao, Chuanhai
Yin, Hang
Cai, Jianfeng
description The last two decades have seen the rise of antimicrobial peptides (AMPs) to combat emerging antibiotic resistance. Herein we report the solid-phase synthesis of short lipidated [alpha]/[gamma]-AA hybrid peptides. This family of lipo-chimeric peptidomimetics displays potent and broad-spectrum antimicrobial activity against a range of multi-drug resistant Gram-positive and Gram-negative bacteria. These lipo-[alpha]/[gamma]-AA hybrid peptides also demonstrate high biological specificity, with no hemolytic activity towards red blood cells. Fluorescence microscopy suggests that these lipo-[alpha]/[gamma]-AA chimeric peptides can mimic the mode of action of AMPs and kill bacterial pathogens via membrane disintegration. As the composition of these chimeric peptides is simple, therapeutic development could be economically feasible and amenable for a variety of antimicrobial applications. [PUBLICATION ABSTRACT]
doi_str_mv 10.1002/cbic.201402264
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subjects Antimicrobial agents
Bacteriology
Peptides
title Short Antimicrobial Lipo-[alpha]/[gamma]-AA Hybrid Peptides
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