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Short Antimicrobial Lipo-[alpha]/[gamma]-AA Hybrid Peptides
The last two decades have seen the rise of antimicrobial peptides (AMPs) to combat emerging antibiotic resistance. Herein we report the solid-phase synthesis of short lipidated [alpha]/[gamma]-AA hybrid peptides. This family of lipo-chimeric peptidomimetics displays potent and broad-spectrum antimic...
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Published in: | Chembiochem : a European journal of chemical biology 2014-10, Vol.15 (15), p.2275 |
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container_title | Chembiochem : a European journal of chemical biology |
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creator | Li, Yaqiong Smith, Christina Wu, Haifan Teng, Peng Shi, Yan Padhee, Shruti Jones, Torey Nguyen, Anh-My Cao, Chuanhai Yin, Hang Cai, Jianfeng |
description | The last two decades have seen the rise of antimicrobial peptides (AMPs) to combat emerging antibiotic resistance. Herein we report the solid-phase synthesis of short lipidated [alpha]/[gamma]-AA hybrid peptides. This family of lipo-chimeric peptidomimetics displays potent and broad-spectrum antimicrobial activity against a range of multi-drug resistant Gram-positive and Gram-negative bacteria. These lipo-[alpha]/[gamma]-AA hybrid peptides also demonstrate high biological specificity, with no hemolytic activity towards red blood cells. Fluorescence microscopy suggests that these lipo-[alpha]/[gamma]-AA chimeric peptides can mimic the mode of action of AMPs and kill bacterial pathogens via membrane disintegration. As the composition of these chimeric peptides is simple, therapeutic development could be economically feasible and amenable for a variety of antimicrobial applications. [PUBLICATION ABSTRACT] |
doi_str_mv | 10.1002/cbic.201402264 |
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Herein we report the solid-phase synthesis of short lipidated [alpha]/[gamma]-AA hybrid peptides. This family of lipo-chimeric peptidomimetics displays potent and broad-spectrum antimicrobial activity against a range of multi-drug resistant Gram-positive and Gram-negative bacteria. These lipo-[alpha]/[gamma]-AA hybrid peptides also demonstrate high biological specificity, with no hemolytic activity towards red blood cells. Fluorescence microscopy suggests that these lipo-[alpha]/[gamma]-AA chimeric peptides can mimic the mode of action of AMPs and kill bacterial pathogens via membrane disintegration. As the composition of these chimeric peptides is simple, therapeutic development could be economically feasible and amenable for a variety of antimicrobial applications. 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subjects | Antimicrobial agents Bacteriology Peptides |
title | Short Antimicrobial Lipo-[alpha]/[gamma]-AA Hybrid Peptides |
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