Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice

Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazone...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2014-07, Vol.47 (4), p.517
Main Authors: Ana, Angélica Amorim Santarem, Gabriel, Frizon Greggianin, Rafaela, Garcia Debastiani, Jefferson, Bruno Pereira Ribeiro, Demerson, Andre Polli, Raimunda, Nonata Ribeiro Sampaio
Format: Article
Language:English
Subjects:
Animal diseases
Cytokines
Parasitic diseases
Parasitic protozoa
Rodents
Vector-borne diseases
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Summary:Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection.
ISSN:0037-8682
1678-9849
DOI:10.1590/0037-8682-0202-201