role of stress in colicin regulation

Bacteriocins produced by Enterobacteriaceae are high molecular weight toxic proteins that kill target cells through a variety of mechanisms, including pore formation and nucleic acid degradation. What is remarkable about these toxins is that their expression results in death to the producing cells a...

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Bibliographic Details
Published in:Archives of microbiology 2014-11, Vol.196 (11), p.753-764
Main Authors: Ghazaryan, Lusine, Tonoyan, Lilit, Ashhab, Ashraf Al, Soares, M. Ines M, Gillor, Osnat
Format: Article
Language:English
Subjects:
anaerobiosis
Bacteria
Bacteriocins - genetics
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cell Biology
cell death
cold stress
colicins
E coli
Ecology
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae - genetics
Enterobacteriaceae - physiology
Environment
Gene Expression Regulation, Bacterial - drug effects
intestinal microorganisms
Life Sciences
Microbial Ecology
Microbiology
molecular weight
mutagenicity
Mutagens - pharmacology
Nucleic acids
Original Paper
osmolarity
Oxidative stress
Plasmids
Promoter Regions, Genetic - genetics
Proteins
stress response
Stress, Physiological
Toxins
Transfer RNA
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Summary:Bacteriocins produced by Enterobacteriaceae are high molecular weight toxic proteins that kill target cells through a variety of mechanisms, including pore formation and nucleic acid degradation. What is remarkable about these toxins is that their expression results in death to the producing cells and therefore bacteriocin induction have to be tightly regulated, often confined to times of stress. Information on the regulation of bacteriocins produced by enteric bacteria is sketchy as their expression has only been elucidated in a handful of bacteria. Here, we review the known regulatory mechanisms of enteric bacteriocins and explore the expression of 12 of them in response to various triggers: DNA-damaging agents, stringent response, catabolite repression, oxidative stress, growth phase, osmolarity, cold shock, nutrient deprivation, anaerobiosis and pH stress. Our results indicate that the expression of bacteriocins is mostly confined to mutagenic triggers, while all other triggers tested are limited inducers.
ISSN:0302-8933
1432-072X
DOI:10.1007/s00203-014-1017-8