Dihydroartemisinin induces autophagy by suppressing NF-...B activation

Nuclear factor-kappa B (NF-...B) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DHA) stimulates the induction of autop...

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Bibliographic Details
Published in:Cancer letters 2014-02, Vol.343 (2), p.239
Main Authors: Hu, Wei, Chen, Sang-Sang, Zhang, Jia-Li, Lou, Xiao-E, Zhou, Hui-Jun
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Cancer
Cancer therapies
Cell growth
Immune system
Oxidative stress
Polyclonal antibodies
Studies
Online Access:Get full text
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Summary:Nuclear factor-kappa B (NF-...B) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DHA) stimulates the induction of autophagy in several cancer cell lines through repression of NF-...B activity. We also show that inhibiting NF-...B results in an accumulation of reactive oxygen species (ROS), which participate in the stimulation of autophagy. These findings present a pathway by which DHA promotes autophagy in cancer cells and provide evidence for the DHA-induced sensitization effect of some chemotherapeutics.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.09.035