HIV and alcohol in blood brain barrier injury and neuroinflammation: Protective effect of cannabinoid type (CB2 ) receptor agonists

Chronic neuroinflammation in HIV infection of the central nervous system (CNS) is driven by low levels of virus replication in brain macrophages, inefficient immune responses against viruses in the brain, and chronic injury of the blood brain barrier (BBB).

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2014-11, Vol.48 (7), p.732-732
Main Authors: Persidsky, Y, Rom, S, Dykstra, H, Reichenbach, N, Ramirez, V, Ramirez, S.H
Format: Article
Language:English
Subjects:
Alcohol
Blood
Blood-brain barrier
Endothelium
HIV
Human immunodeficiency virus
Infections
Psychiatry
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Description
Summary:Chronic neuroinflammation in HIV infection of the central nervous system (CNS) is driven by low levels of virus replication in brain macrophages, inefficient immune responses against viruses in the brain, and chronic injury of the blood brain barrier (BBB).
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2014.09.023