Hepatocellular adenoma showing high uptake of18F-fluorodeoxyglucose (FDG) via an increased expression of glucose transporter 2 (GLUT-2)

Hepatocellular adenoma (HCA) is a benign liver neoplasm composed of hepatocytes. We experienced HCA demonstrating a high uptake of18F-fluorodeoxyglucose (FDG) on positron emission tomography-computed tomography, mimicking a malignant tumor. The mechanism underlying the uptake of FDG has not been ide...

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Bibliographic Details
Published in:Clinical imaging 2014-11, Vol.38 (6), p.888
Main Authors: Nakashima, Takaaki, Takayama, Yukihisa, Nishie, Akihiro, Asayama, Yoshiki, Baba, Shingo, Yamashita, Youichi, Shirabe, Ken, Kubo, Yuichiro, Hida, Tomoyuki, Honda, Hiroshi
Format: Article
Language:English
Subjects:
Contrast agents
Disease
Hemorrhage
Medical imaging
Metabolism
NMR
Nuclear magnetic resonance
Rodents
Studies
Tomography
Tumors
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Summary:Hepatocellular adenoma (HCA) is a benign liver neoplasm composed of hepatocytes. We experienced HCA demonstrating a high uptake of18F-fluorodeoxyglucose (FDG) on positron emission tomography-computed tomography, mimicking a malignant tumor. The mechanism underlying the uptake of FDG has not been identified. Here, we discuss that an enhancement of glucose metabolism via an increased expression of glucose transporter 2 may have a role in the high uptake of FDG shown by HCAs.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2014.06.005