Presumptive nonthyroidal illness syndrome in critically ill foals

Reasons for performing the study: Hypothalamic‐pituitary‐thyroid (HPT) axis dysfunction is associated with morbidity and mortality in critically ill people. To date, investigations of HPT axis in critically ill foals are limited. Objectives: To document the occurrence of low thyroid hormone concentr...

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Published in:Equine veterinary journal 2012-02, Vol.44 (s41), p.43-47
Main Authors: HIMLER, M, HURCOMBE, S. D. A, GRIFFIN, A, BARSNICK, R. J, RATHGEBER, R. A, MACGILLIVRAY, K. C, TORIBIO, R. E
Format: Article
Language:English
Subjects:
disease severity
euthyroid sick syndrome
foal
foals
Hormones
Illnesses
morbidity
mortality
neonates
people
prematurity
radioimmunoassays
Sepsis
sepsis (infection)
therapeutics
thyroid
thyroxine
triiodothyronine
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cited_by cdi_FETCH-LOGICAL-c4750-2effd60817b0489d48408b510a9305c6b086cb2835b258863cce7f4f2a32fc343
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container_end_page 47
container_issue s41
container_start_page 43
container_title Equine veterinary journal
container_volume 44
creator HIMLER, M
HURCOMBE, S. D. A
GRIFFIN, A
BARSNICK, R. J
RATHGEBER, R. A
MACGILLIVRAY, K. C
TORIBIO, R. E
description Reasons for performing the study: Hypothalamic‐pituitary‐thyroid (HPT) axis dysfunction is associated with morbidity and mortality in critically ill people. To date, investigations of HPT axis in critically ill foals are limited. Objectives: To document the occurrence of low thyroid hormone concentrations (presumptive nonthyroidal illness syndrome; NTIS) in critically ill newborn foals and investigate whether NTIS is associated with severity of disease and outcome. Hypothesis: NTIS occurs frequently in foals with sepsis and is associated with sepsis score and outcome. Reverse T3 (rT3) concentrations will be increased in septic foals and highest in nonsurvivors. Methods: Thyroid hormones (total and free thyroxine [TT4 and fT4], total and free tri‐iodothyronine [TT3 and fT3], reverse T3 [rT3]) were prospectively measured in healthy, sick nonseptic and septic foals. Clinical and laboratory information was retrieved from the medical records. Hormones were measured by validated radioimmunoassays. Results: Concentrations of all thyroid hormones except rT3 (P = 0.69) were decreased in septic and sick nonseptic foals (P
doi_str_mv 10.1111/j.2042-3306.2011.00480.x
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D. A ; GRIFFIN, A ; BARSNICK, R. J ; RATHGEBER, R. A ; MACGILLIVRAY, K. C ; TORIBIO, R. E</creator><creatorcontrib>HIMLER, M ; HURCOMBE, S. D. A ; GRIFFIN, A ; BARSNICK, R. J ; RATHGEBER, R. A ; MACGILLIVRAY, K. C ; TORIBIO, R. E</creatorcontrib><description>Reasons for performing the study: Hypothalamic‐pituitary‐thyroid (HPT) axis dysfunction is associated with morbidity and mortality in critically ill people. To date, investigations of HPT axis in critically ill foals are limited. Objectives: To document the occurrence of low thyroid hormone concentrations (presumptive nonthyroidal illness syndrome; NTIS) in critically ill newborn foals and investigate whether NTIS is associated with severity of disease and outcome. Hypothesis: NTIS occurs frequently in foals with sepsis and is associated with sepsis score and outcome. Reverse T3 (rT3) concentrations will be increased in septic foals and highest in nonsurvivors. Methods: Thyroid hormones (total and free thyroxine [TT4 and fT4], total and free tri‐iodothyronine [TT3 and fT3], reverse T3 [rT3]) were prospectively measured in healthy, sick nonseptic and septic foals. Clinical and laboratory information was retrieved from the medical records. Hormones were measured by validated radioimmunoassays. Results: Concentrations of all thyroid hormones except rT3 (P = 0.69) were decreased in septic and sick nonseptic foals (P&lt;0.01). Reductions in hormone concentrations were associated with an increased sepsis score (P&lt;0.01). Nonsurviving septic foals had lower TT4, fT4, TT3 and fT3 concentrations than surviving septic foals (P&lt;0.01). rT3 concentrations were higher in nonsurviving septic premature foals than surviving septic premature foals (P&lt;0.05). Conclusions: NTIS (euthyroid sick syndrome) is frequently observed in critically ill and premature foals, and associated with severity of disease and mortality. Potential relevance: More research is needed to better understand the mechanism of this finding and determine whether manipulation of the HPT axis or thyroid replacement therapy could be beneficial.</description><identifier>ISSN: 0425-1644</identifier><identifier>EISSN: 2042-3306</identifier><identifier>DOI: 10.1111/j.2042-3306.2011.00480.x</identifier><identifier>CODEN: EQVJAI</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>disease severity ; euthyroid sick syndrome ; foal ; foals ; Hormones ; Illnesses ; morbidity ; mortality ; neonates ; people ; prematurity ; radioimmunoassays ; Sepsis ; sepsis (infection) ; therapeutics ; thyroid ; thyroxine ; triiodothyronine</subject><ispartof>Equine veterinary journal, 2012-02, Vol.44 (s41), p.43-47</ispartof><rights>2012 EVJ Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4750-2effd60817b0489d48408b510a9305c6b086cb2835b258863cce7f4f2a32fc343</citedby><cites>FETCH-LOGICAL-c4750-2effd60817b0489d48408b510a9305c6b086cb2835b258863cce7f4f2a32fc343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>HIMLER, M</creatorcontrib><creatorcontrib>HURCOMBE, S. D. A</creatorcontrib><creatorcontrib>GRIFFIN, A</creatorcontrib><creatorcontrib>BARSNICK, R. J</creatorcontrib><creatorcontrib>RATHGEBER, R. A</creatorcontrib><creatorcontrib>MACGILLIVRAY, K. C</creatorcontrib><creatorcontrib>TORIBIO, R. E</creatorcontrib><title>Presumptive nonthyroidal illness syndrome in critically ill foals</title><title>Equine veterinary journal</title><description>Reasons for performing the study: Hypothalamic‐pituitary‐thyroid (HPT) axis dysfunction is associated with morbidity and mortality in critically ill people. To date, investigations of HPT axis in critically ill foals are limited. Objectives: To document the occurrence of low thyroid hormone concentrations (presumptive nonthyroidal illness syndrome; NTIS) in critically ill newborn foals and investigate whether NTIS is associated with severity of disease and outcome. Hypothesis: NTIS occurs frequently in foals with sepsis and is associated with sepsis score and outcome. Reverse T3 (rT3) concentrations will be increased in septic foals and highest in nonsurvivors. Methods: Thyroid hormones (total and free thyroxine [TT4 and fT4], total and free tri‐iodothyronine [TT3 and fT3], reverse T3 [rT3]) were prospectively measured in healthy, sick nonseptic and septic foals. Clinical and laboratory information was retrieved from the medical records. Hormones were measured by validated radioimmunoassays. Results: Concentrations of all thyroid hormones except rT3 (P = 0.69) were decreased in septic and sick nonseptic foals (P&lt;0.01). Reductions in hormone concentrations were associated with an increased sepsis score (P&lt;0.01). Nonsurviving septic foals had lower TT4, fT4, TT3 and fT3 concentrations than surviving septic foals (P&lt;0.01). rT3 concentrations were higher in nonsurviving septic premature foals than surviving septic premature foals (P&lt;0.05). Conclusions: NTIS (euthyroid sick syndrome) is frequently observed in critically ill and premature foals, and associated with severity of disease and mortality. Potential relevance: More research is needed to better understand the mechanism of this finding and determine whether manipulation of the HPT axis or thyroid replacement therapy could be beneficial.</description><subject>disease severity</subject><subject>euthyroid sick syndrome</subject><subject>foal</subject><subject>foals</subject><subject>Hormones</subject><subject>Illnesses</subject><subject>morbidity</subject><subject>mortality</subject><subject>neonates</subject><subject>people</subject><subject>prematurity</subject><subject>radioimmunoassays</subject><subject>Sepsis</subject><subject>sepsis (infection)</subject><subject>therapeutics</subject><subject>thyroid</subject><subject>thyroxine</subject><subject>triiodothyronine</subject><issn>0425-1644</issn><issn>2042-3306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkVtP3DAQhS0EEtttfwOR-pxlfI2R-oK2XAqoVGppH0eO16beZpPFztLNv8dpKp7xyxxpzjdjHxNSUFjQfE7XCwaClZyDyorSBYDQsNgfkNlr45DMspQlVUIck3cprQE4Z4LNyPm36NJus-3Dsyvaru1_D7ELK9MUoWlal1KRhnYVu40rQlvYGPpgTdMMY7vwnWnSe3Lkc3Ef_tc5ebi8-LG8Lu_ur74sz-9KKyoJJXPerxRoWtX5gmcroQXoWlIwZxykVTVoZWumuayZ1Fpxa13lhWeGM2-54HPycZq7jd3TzqUe190utnklUkUrlh-a6TnRk8vGLqXoPG5j2Jg4IAUcA8M1jrngmAuOgeG_wHCf0U8T-jc0bngzhxc_b7LIeDnhIfVu_4qb-AdVxSuJv75e4VJf31CpP-Nt9p9Mfm86NI8xJHz4ngdLgPxPKifwAhcPiD0</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>HIMLER, M</creator><creator>HURCOMBE, S. D. A</creator><creator>GRIFFIN, A</creator><creator>BARSNICK, R. J</creator><creator>RATHGEBER, R. A</creator><creator>MACGILLIVRAY, K. C</creator><creator>TORIBIO, R. E</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201202</creationdate><title>Presumptive nonthyroidal illness syndrome in critically ill foals</title><author>HIMLER, M ; HURCOMBE, S. D. A ; GRIFFIN, A ; BARSNICK, R. J ; RATHGEBER, R. A ; MACGILLIVRAY, K. C ; TORIBIO, R. 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J</creatorcontrib><creatorcontrib>RATHGEBER, R. A</creatorcontrib><creatorcontrib>MACGILLIVRAY, K. C</creatorcontrib><creatorcontrib>TORIBIO, R. E</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>Equine veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIMLER, M</au><au>HURCOMBE, S. D. A</au><au>GRIFFIN, A</au><au>BARSNICK, R. J</au><au>RATHGEBER, R. A</au><au>MACGILLIVRAY, K. C</au><au>TORIBIO, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presumptive nonthyroidal illness syndrome in critically ill foals</atitle><jtitle>Equine veterinary journal</jtitle><date>2012-02</date><risdate>2012</risdate><volume>44</volume><issue>s41</issue><spage>43</spage><epage>47</epage><pages>43-47</pages><issn>0425-1644</issn><eissn>2042-3306</eissn><coden>EQVJAI</coden><abstract>Reasons for performing the study: Hypothalamic‐pituitary‐thyroid (HPT) axis dysfunction is associated with morbidity and mortality in critically ill people. To date, investigations of HPT axis in critically ill foals are limited. Objectives: To document the occurrence of low thyroid hormone concentrations (presumptive nonthyroidal illness syndrome; NTIS) in critically ill newborn foals and investigate whether NTIS is associated with severity of disease and outcome. Hypothesis: NTIS occurs frequently in foals with sepsis and is associated with sepsis score and outcome. Reverse T3 (rT3) concentrations will be increased in septic foals and highest in nonsurvivors. Methods: Thyroid hormones (total and free thyroxine [TT4 and fT4], total and free tri‐iodothyronine [TT3 and fT3], reverse T3 [rT3]) were prospectively measured in healthy, sick nonseptic and septic foals. Clinical and laboratory information was retrieved from the medical records. Hormones were measured by validated radioimmunoassays. Results: Concentrations of all thyroid hormones except rT3 (P = 0.69) were decreased in septic and sick nonseptic foals (P&lt;0.01). Reductions in hormone concentrations were associated with an increased sepsis score (P&lt;0.01). Nonsurviving septic foals had lower TT4, fT4, TT3 and fT3 concentrations than surviving septic foals (P&lt;0.01). rT3 concentrations were higher in nonsurviving septic premature foals than surviving septic premature foals (P&lt;0.05). Conclusions: NTIS (euthyroid sick syndrome) is frequently observed in critically ill and premature foals, and associated with severity of disease and mortality. Potential relevance: More research is needed to better understand the mechanism of this finding and determine whether manipulation of the HPT axis or thyroid replacement therapy could be beneficial.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1111/j.2042-3306.2011.00480.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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2042-3306
language eng
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source Wiley-Blackwell Read & Publish Collection
subjects disease severity
euthyroid sick syndrome
foal
foals
Hormones
Illnesses
morbidity
mortality
neonates
people
prematurity
radioimmunoassays
Sepsis
sepsis (infection)
therapeutics
thyroid
thyroxine
triiodothyronine
title Presumptive nonthyroidal illness syndrome in critically ill foals
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