Protective efficacy of heat-inactivatedB. thailandensis,B. malleiorB. pseudomalleiagainst experimental melioidosis and glanders

Burkholderia pseudomalleiandBurkholderia malleiare gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases. There is currently no vaccine available for the prevention of disease. We report the protective...

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Bibliographic Details
Published in:Vaccine 2009-07, Vol.27 (33), p.4447
Main Authors: Sarkar-Tyson, Mitali, Smither, Sophie J, Harding, SV, Atkins, Timothy P, Titball, Richard W
Format: Article
Language:English
Subjects:
Animals
Antigens
Bacteria
Bacteriology
Diabetes
Disease
Immunization
Infections
Studies
Vaccines
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Summary:Burkholderia pseudomalleiandBurkholderia malleiare gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases. There is currently no vaccine available for the prevention of disease. We report the protective efficacy of heat-inactivatedBurkholderia thailandensis,B. malleiorB. pseudomalleicells as vaccines against murine melioidosis and glanders. Immunisation with heat-inactivatedB. pseudomalleicells provided the highest levels of protection against either melioidosis or glanders. These studies indicate the longer term potential for heat-inactivated bacteria to be developed as vaccines against melioidosis and glanders.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.05.040