Characterization and antigenicity of the promising vaccine candidatePlasmodium vivax34kDa rhoptry antigen (Pv34)

This study describes the identification of thePlasmodium vivaxrhoptry antigen Pv34 whose sequence was obtained based on homology comparison with thePlasmodium falciparumPf34. Thepv34gene product was characterized by molecular biology and immunological techniques. Additionally, association of Pv34 to...

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Bibliographic Details
Published in:Vaccine 2009-12, Vol.28 (2), p.415
Main Authors: Mongui, Alvaro, Angel, Diana I, Gallego, Gina, Reyes, Claudia, Martinez, Paola, Guhl, Felipe, Patarroyo, Manuel A
Format: Article
Language:English
Subjects:
Bioinformatics
Blood
Candidates
Cytokines
Erythrocytes
Genomes
Genomics
Immunogenicity
Lymphocytes
Malaria
Molecular biology
Molecular weight
Parasites
Parasitic diseases
Peptides
Proteins
Software
Vaccines
Vector-borne diseases
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Summary:This study describes the identification of thePlasmodium vivaxrhoptry antigen Pv34 whose sequence was obtained based on homology comparison with thePlasmodium falciparumPf34. Thepv34gene product was characterized by molecular biology and immunological techniques. Additionally, association of Pv34 to detergent-resistant microdomains (DRMs), expression in late blood-stage parasites and recognition of recombinant Pv34 (rPv34) by sera fromP. vivax-infectedAotusmonkeys and patients was assessed. Lymphoproliferation and cytokine secretion was also evaluated in individuals living in malaria endemic areas. Altogether, the data support carrying out further studies to assess the immunogenicity and protection-inducing ability of rPv34 as component of a multi-antigenic, multi-stage vaccine against vivax malaria.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.10.034