An investigational tetravalent meningococcal serogroups A, C, W-135 and Y-tetanus toxoid conjugate vaccine co-administered withInfanrix(TM) hexa is immunogenic, with an acceptable safety profile in 12-23-month-old children

Tetravalent meningococcal serogroups ACWY conjugate vaccines will provide an advantage to those at most risk of invasive meningococcal disease; namely young children. Co-administration of ACWY-TT with DTaP-HBV-IPV/Hib was assessed in a randomized trial in 793 children aged 12-23 months. Pre-specifie...

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Bibliographic Details
Published in:Vaccine 2011-06, Vol.29 (25), p.4264
Main Authors: Knuf, Markus, Pantazi-Chatzikonstantinou, Anna, Pfletschinger, Ulrich, Tichmann-Schumann, Irmingard, Maurer, Hartwig, Maurer, Lothar, Fischbach, Thomas, Zinke, Henrike, Pankow-Culot, Heidemarie, Papaevan gelou, Vassiliki, Bianco, Veronique, van der Wielen, Marie, Miller, Jacqueline M
Format: Article
Language:English
Subjects:
Age
Antigens
Confidence intervals
Hepatitis
Immunogenicity
Licenses
Meningitis
Poliomyelitis
Preschool children
Teenagers
Tetanus
Vaccines
Whooping cough
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Summary:Tetravalent meningococcal serogroups ACWY conjugate vaccines will provide an advantage to those at most risk of invasive meningococcal disease; namely young children. Co-administration of ACWY-TT with DTaP-HBV-IPV/Hib was assessed in a randomized trial in 793 children aged 12-23 months. Pre-specified criteria for non-inferiority of immunogenicity following co-administration versus separate ACWY-TT and DTaP-HBV-IPV/Hib administration were reached. One month post-vaccination, >=97.3% of ACWY-TT vaccinees had rSBA titres >=1:8 (all serogroups). Seroprotection/seropositivity rates against DTaP-HBV-IPV/Hib antigens were >=98.2%. The safety profile of co-administration was similar to that of DTaP-HBV-IPV/Hib alone. ACWY-TT and DTaP-HBV-IPV/Hib co-administration during the second year would facilitate introduction of ACWY-TT into routine toddler vaccination schedules.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.03.009