DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid [beta]-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

Highlights * Can vaccine for Alzheimer's disease (AD) be effective at the onset of the disease? * Vaccine use in old mice ameliorates cognitive AD impairments. * Vaccine provides survival benefit and prolongs life span of AD mice.

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Bibliographic Details
Published in:Vaccine 2012-02, Vol.30 (9), p.1650
Main Authors: Olkhanud, Purevdorj B, Mughal, Mohammed, Ayukawa, Koichi, Malchinkhuu, Enkhzol, Bodogai, Monica, Feldman, Neil, Rothman, Sarah, Lee, Jong-Hwan, Chigurupati, Srinivasulu, Okun, Eitan, Nagashima, Kunio, Mattson, Mark P, Biragyn, Arya
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Animal cognition
Atoms & subatomic particles
Brain research
Clinical trials
Deoxyribonucleic acid
DNA
Immunization
Laboratory animals
Lymphocytes
Mortality
Peptides
Rodents
Vaccines
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Description
Summary:Highlights * Can vaccine for Alzheimer's disease (AD) be effective at the onset of the disease? * Vaccine use in old mice ameliorates cognitive AD impairments. * Vaccine provides survival benefit and prolongs life span of AD mice.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.12.136