The adjuvanticity ofChiococca albasaponins increases with the length and hydrophilicity of their sugar chains

Highlights * We examine four differentChiococca albasaponins containing 2, 3 and 4 sugar units. * The best adjuvant potential was found in the four sugar units-saponin called CA4. * CA4 was used for vaccination with the FML antigen ofLeishmania donovani. * CA4 induced a CD4+-TNF-α mediated protectio...

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Bibliographic Details
Published in:Vaccine 2012-05, Vol.30 (21), p.3169
Main Authors: Nico, Dirlei, Borges, Ricardo Moreira, Brandão, Layza Mendes, Feijó, Daniel Ferreira, Gomes, Daniele Crespo, Palatnik, Marcos, Rodrigues, Mauricio Martins, da Silva, Antonio Jorge Ribeiro, Palatnik-de-Sousa, Clarisa Beatriz
Format: Article
Language:English
Subjects:
Acids
Antigens
Carbohydrates
Dogs
Lymphocytes
Parasitic diseases
Sugar
Vaccines
Vector-borne diseases
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Summary:Highlights * We examine four differentChiococca albasaponins containing 2, 3 and 4 sugar units. * The best adjuvant potential was found in the four sugar units-saponin called CA4. * CA4 was used for vaccination with the FML antigen ofLeishmania donovani. * CA4 induced a CD4+-TNF-α mediated protection against murine visceral leishmaniasis. * Adjuvanticity increases with the length and hydrophilicity of saponins sugar chains.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.03.006