Comparison of Thyroid Blood Flow and Uptake Indices Using Technetium-99m Pertechnetate in Patients with Graves' Disease and Euthyroid Subjects/Graves' Hastaligi olan Hastalarda ve Ötiroid Kisilerde Teknesyum 99m Perteknetat ile Tiroid Kan Akimi ve Uptake Indekslerinin Karsilastirilmasi

• Published in: Molecular imaging and radionuclide therapy 2014-10, Vol.23 (3), p.96
• Main Authors: Javadi, Hamid, Pashazadeh, Ali Mahmoud, Mogharrabi, Mehdi, Nabipour, Iraj, Kalantarhormozi, Mohammadreza, Assadi, Majid
• Format: Article
• Language: English
• ISSN: 2146-1414; 2147-1959

The aim of the present study was to evaluate parameters of early blood flow (EBF) including duration of EBF, perfusion index (PI), uptake indexes 1 and 2 (UI1 and UI2) derived from dynamic thyroid scintigraphy in patients with Graves' disease (GD), and euthyroid (EI). Maximum instant uptake and maximum uptake of the thyroid gland were also assessed. A total of 50 patients with GD and EI were included in this study. Each patient underwent two dynamic scans of 1-minute and 20-minute with ^sup 99m^TcO4. The time-activity curve of a 1-minute scan was employed to derive EBF parameters; likewise, the time-activity curve of a 20-minute scan was used to determine maximum instant uptake, and the gradient of the curve from the 10th to 20th minute was used to assess maximum uptake. Values of EBF duration, PI, UI1, UI2, and maximum instant uptake were significantly lower in patients with GD than in those with EI (p < 0.05).