CXCR2 inhibition protects against chronic pancreatitis in a murine model

To examine the importance of neutrophils in this process we used a neutrophil blocking antibody and found that there was significant pancreatic damage from macrophage infiltration despite neutrophil blockade. [...]CXCR2 inhibition may protect patients with early chronic pancreatitis from pancreatic...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-01, Vol.13 (1), p.e5-e5
Main Authors: Steele, C.W, Morton, J.P, McKay, C.J, Evans, T.R.J, Carter, C.R, Sansom, O.J
Format: Article
Language:English
Subjects:
Chemokines
Endocrinology & Metabolism
Gastroenterology and Hepatology
Pancreas
Rodents
Online Access:Get full text
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Summary:To examine the importance of neutrophils in this process we used a neutrophil blocking antibody and found that there was significant pancreatic damage from macrophage infiltration despite neutrophil blockade. [...]CXCR2 inhibition may protect patients with early chronic pancreatitis from pancreatic damage in a process dependent on both neutrophil and macrophage chemotaxis.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2012.12.016