One-pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalysed by Cupric Acetate under Solvent-free Conditions

• Published in: Journal of the Chinese Chemical Society (Taipei) 2014-11, Vol.61 (11), p.1254-1258
• Main Authors: Kathing, Chingrishon, Rani, Jims World Star, Singh, Nongthombam Geetmani, Tumtin, Shokip, Nongrum, Ridaphun, Nongkhlaw, Rishanlang
• Format: Article
• Language: English
• Subjects: Cupric acetate; Dihydropyrimidinones; Solvent-free
• ISSN: 0009-4536; 2192-6549
• DOI: 10.1002/jccs.201400041

A solvent‐free synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones from aromatic aldehydes, β‐keto ester/acetyl acetone and urea catalysed by cupric acetate under thermal condition is reported as a simple and an efficient protocol. Compared with classical Biginelli reaction reported in 1893, this new method provides much improved modification in terms of yield and reaction time. The usage of milder catalyst, environmental friendly procedures and excellent yields within a very short time (5–15 min) are the advantages of the method in which the involvement of solvent‐free condition adds an edge to the method. Thus, the efficiency of the protocol enabled the rapid synthesis of 3,4‐dihydropyrimidin‐2(1H)‐one derivatives in a short duration. A solvent‐free synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones from aromatic aldehydes, β‐keto ester/acetyl acetone and urea catalysed by cupric acetate under thermal condition is reported as a simple and an efficient protocol. The usage of milder catalyst, environmental friendly procedures and excellent yields within a very short duration are the advantages of the method in which the involvement of solvent‐free condition adds an edge to the method.