One-pot synthesis of 3,4-dihydro-3-hydroxyisochroman-1-one and evaluation of acetal derivatives as antibacterial and antifungal agents

A one-pot synthesis of 3,4-dihydro-3-hydroxyisochroman-1-one (lactol) by oxidation of indene using tungstic acid-hydrogen peroxide is reported. The synthesized lactol was converted into acetal derivatives , which were evaluated for their antibacterial activity against , (Gram-positive), , (Gram-nega...

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Bibliographic Details
Published in:Heterocyclic communications 2014-10, Vol.20 (5), p.299-303
Main Authors: Patel, Gautam M., Deota, Pradeep T.
Format: Article
Language:English
Subjects:
3,4-dihydro-3-hydroxyisochroman-1-one
acetals
antibacterial
Antibiotics
antifungal
Bacteriology
Chemical synthesis
lactol
Pharmacology
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Summary:A one-pot synthesis of 3,4-dihydro-3-hydroxyisochroman-1-one (lactol) by oxidation of indene using tungstic acid-hydrogen peroxide is reported. The synthesized lactol was converted into acetal derivatives , which were evaluated for their antibacterial activity against , (Gram-positive), , (Gram-negative) strains, and antifungal activity against and by broth dilution method. The compounds show potent activity against in comparison with ampicillin and exhibit modest antifungal activity.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2014-0136