Influence of theIxodes ricinustick blood-feeding on the antigen-specific antibody responsein vivo

The blood meal of hard ticks such asIxodes ricinuslasts several days. This is made possible by tick salivary factors that inhibit inflammation, haemostasis and the host immune response. We assessed the latter on a model of immune responsein vivo. A significant reduction of specific IgM and IgG level...

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Bibliographic Details
Published in:Vaccine 2008-12, Vol.26 (52), p.6956
Main Authors: Menten-Dedoyart, C, Couvreur, B, Thellin, O, Drion, PV, Herry, M, Jolois, O, Heinen, E
Format: Article
Language:English
Subjects:
Blood
Immune response
Immune system
Immunization
Insect bites
Lyme disease
Lymph nodes
Lymphocytes
Subpopulations
Vaccines
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Summary:The blood meal of hard ticks such asIxodes ricinuslasts several days. This is made possible by tick salivary factors that inhibit inflammation, haemostasis and the host immune response. We assessed the latter on a model of immune responsein vivo. A significant reduction of specific IgM and IgG levels was observed in BALB/c mice infested 5 days before injection with bovine serum albumin (BSA) and QuilA but not in mice infested 5 days after the immunization. This effect was not observed in mock-infested mice and could not be attributed to the use of anesthetics. The antibody response was not merely delayed and the Th1/Th2balance appeared not altered. T-dependent zones and germinal centers in lymph nodes draining the tick bite site showed no apparent morphological alterations or shift in T cell subpopulations. However, the spleens of tick-infested mice had also an enlarged red pulp, indicating an increased extramedullary haematopoietic activity.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.09.072