Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guerin expressing thePlasmodium falciparumcircumsporozoite induces enhanced long-term memory immunity in BALB/c mice

Highlights * The heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger type 1 CSp-specific IFN-γ-producing cells. * The heterologous prime-boost regimen Ad35-CS/BCG-CS induces higher levels of cytophilic IgG2a. * The heterologous prime-boost regimen Ad35-CS/BCG-CS regimen elicits the high...

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Bibliographic Details
Published in:Vaccine 2012-06, Vol.30 (27), p.4040
Main Authors: Arama, Charles, Assefaw-Redda, Yohannes, Rodriguez, Ariane, Fernández, Carmen, Corradin, Giampietro, Kaufmann, Stefan HE, Reece, Stephen T, Troye-Blomberg, Marita
Format: Article
Language:English
Subjects:
Antigens
Immune system
Malaria
Parasites
Vaccines
Online Access:Get full text
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Summary:Highlights * The heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger type 1 CSp-specific IFN-γ-producing cells. * The heterologous prime-boost regimen Ad35-CS/BCG-CS induces higher levels of cytophilic IgG2a. * The heterologous prime-boost regimen Ad35-CS/BCG-CS regimen elicits the highest level of LLPC-mediated immune responses.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.04.029