Immunity to Staphylococcus aureussecreted proteins protects rabbits from serious illnesses

Highlights * Vaccination againstStaphylococcus aureusis achieved with toxoids. * Toxoids are >107inactivated and stimulate immunity toS. aureus. * Superantigen toxoids exhibit adjuvant activity dependent on immune co-stimulatory molecule CD40 binding activity. * Protective neutralizing antibodies...

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Bibliographic Details
Published in:Vaccine 2012-07, Vol.30 (34), p.5099
Main Authors: Spaulding, Adam R, Lin, Ying-Chi, Merriman, Joseph A, Brosnahan, Amanda J, Peterson, Marnie L, Schlievert, Patrick M
Format: Article
Language:English
Subjects:
Antibiotics
Antigens
Bacteriology
Endothelium
Laboratories
Mutation
Older people
Pneumonia
Rabbits
Sepsis
Staphylococcus infections
Studies
Toxins
Vaccines
Vegetation
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Summary:Highlights * Vaccination againstStaphylococcus aureusis achieved with toxoids. * Toxoids are >107inactivated and stimulate immunity toS. aureus. * Superantigen toxoids exhibit adjuvant activity dependent on immune co-stimulatory molecule CD40 binding activity. * Protective neutralizing antibodies are produced in rabbits to toxic shock syndrome toxin-1.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.05.067