In vitro assessment of halobacterial gas vesicles as aChlamydiavaccine display and delivery system

Highlights * Gas vesicles (Gv) displayChlamydiaproteins as part of their membrane structures. * Recombinant gas vesicles (r-Gv) are readily recognized by human immune sera. * Gv engage TLRs and stimulate proinflammatory cytokines in a peptide-specific manner. * Temporal degradation of Gv in vitro, c...

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Bibliographic Details
Published in:Vaccine 2012-09, Vol.30 (41), p.5942
Main Authors: Childs, Tawanna S, Webley, Wilmore C
Format: Article
Language:English
Subjects:
Antibiotics
Antigens
Cloning
Cytokines
Deoxyribonucleic acid
DNA
Gases
Infections
Laboratories
Peptides
Plasmids
Proteins
Sexually transmitted diseases
STD
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Summary:Highlights * Gas vesicles (Gv) displayChlamydiaproteins as part of their membrane structures. * Recombinant gas vesicles (r-Gv) are readily recognized by human immune sera. * Gv engage TLRs and stimulate proinflammatory cytokines in a peptide-specific manner. * Temporal degradation of Gv in vitro, culminates in antigen display at cell surface. * R-Gv promise to be an ideal multisubunit vaccine display/delivery platform.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.07.038