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Actively induced antigen-specific CD8+T cells by epitope-bearing parasite pre-infection but not prime/boost virus vector vaccination could ameliorate the course ofPlasmodium yoeliiblood-stage infection
Highlights * Genetically engineered malaria enabled the analyses of CD8+T cells against MBS. * The CD8+T cells induced by the virus-vector vaccine failed to ameliorate the MBS infection. * The CD8+T cells induced byT. cruzipre-infection ameliorated the MBS infection. * This is the first study to imp...
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Published in: | Vaccine 2012-09, Vol.30 (44), p.6270 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Highlights * Genetically engineered malaria enabled the analyses of CD8+T cells against MBS. * The CD8+T cells induced by the virus-vector vaccine failed to ameliorate the MBS infection. * The CD8+T cells induced byT. cruzipre-infection ameliorated the MBS infection. * This is the first study to implicate the active roles of CD8+T cells against MBS. |
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ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2012.08.009 |