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Actively induced antigen-specific CD8+T cells by epitope-bearing parasite pre-infection but not prime/boost virus vector vaccination could ameliorate the course ofPlasmodium yoeliiblood-stage infection

Highlights * Genetically engineered malaria enabled the analyses of CD8+T cells against MBS. * The CD8+T cells induced by the virus-vector vaccine failed to ameliorate the MBS infection. * The CD8+T cells induced byT. cruzipre-infection ameliorated the MBS infection. * This is the first study to imp...

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Bibliographic Details
Published in:Vaccine 2012-09, Vol.30 (44), p.6270
Main Authors: Ono, Takeshi, Yamaguchi, Yoko, Oguma, Takemi, Takayama, Eiji, Takashima, Yasuhiro, Tadakuma, Takushi, Miyahira, Yasushi
Format: Article
Language:English
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Summary:Highlights * Genetically engineered malaria enabled the analyses of CD8+T cells against MBS. * The CD8+T cells induced by the virus-vector vaccine failed to ameliorate the MBS infection. * The CD8+T cells induced byT. cruzipre-infection ameliorated the MBS infection. * This is the first study to implicate the active roles of CD8+T cells against MBS.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.08.009