Intratumoral injection of attenuatedSalmonellavaccine can induce tumor microenvironmental shift from immune suppressive to immunogenic

Highlights * Attenuated Salmonella vaccine (RASV) significantly inhibited tumor growth. * RASV significantly increased TNF-α-secreting CD11b+Gr-1+myeloid cells. * RASV significantly reduced CD4+CD25+Foxp3+Tregs. * RASV can induce a tumor microenvironmental shift from suppressive to immunogenic.

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Bibliographic Details
Published in:Vaccine 2013-02, Vol.31 (10), p.1377
Main Authors: Hong, Eun-Hye, Chang, Sun-Young, Lee, Bo-Ra, Pyun, A-Rim, Kim, Ji-Won, Kweon, Mi-Na, Ko, Hyun-Jeong
Format: Article
Language:English
Subjects:
Bacterial infections
Immune system
Rodents
Salmonella
Vaccines
Online Access:Get full text
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Summary:Highlights * Attenuated Salmonella vaccine (RASV) significantly inhibited tumor growth. * RASV significantly increased TNF-α-secreting CD11b+Gr-1+myeloid cells. * RASV significantly reduced CD4+CD25+Foxp3+Tregs. * RASV can induce a tumor microenvironmental shift from suppressive to immunogenic.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.01.006