GW25-e5207 Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canine

Myocardial proangiogenic factors stromal cell-derived factor 1 (SDF-1), hypoxia-inducible factors 1 (HIF-1, a transcription factor which could regulate SDF-1 expression), serum SDF-1 levels and circulating EPCs mobilization greatly elevated after 3 weeks pacing but nearly returned to baseline level...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2014-10, Vol.64 (16), p.C27-C27
Main Authors: Jingting, M.A.I, Chen, YangXin, Qiu, Qiong, Yuan, WoLiang, Wang, JingFeng
Format: Article
Language:English
Subjects:
Angiogenesis
Cardiac arrhythmia
Cardiology
Cardiovascular
Dogs
Heart failure
Internal Medicine
Online Access:Get full text
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Summary:Myocardial proangiogenic factors stromal cell-derived factor 1 (SDF-1), hypoxia-inducible factors 1 (HIF-1, a transcription factor which could regulate SDF-1 expression), serum SDF-1 levels and circulating EPCs mobilization greatly elevated after 3 weeks pacing but nearly returned to baseline level after 6 weeks pacing, which were in accordance with the changes of neovascularization levels assessed by CD105.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.06.132