GW25-e0865 Cardiac Stem Cell Transplantation Improve Electrophysiological Stability in Rats with Myocardial Infarction via Inhibition of TGF-[beta]1 Pathway

Methods MI was induced in 30 male Sprague-Dawley rats. 2 weeks later, animals were randomized to receive 5x106 CSCs labeled with PKH26 in PBS, 5x106 MSCs labeled with PKH26 in phosphate buffer solution (PBS) or PBS alone injection into the infarcted anterior ventricular free wall (10 rats for each g...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2014-10, Vol.64 (16), p.C6
Main Authors: Shaoxin, Zheng, Tong, Wang, Jingying, Hou, Peifen, Liang, Yanling, Fang, Tianzhu, Guo, Jingfeng, Wang
Format: Article
Language:English
Subjects:
Cardiology
Rodents
Stem cells
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Summary:Methods MI was induced in 30 male Sprague-Dawley rats. 2 weeks later, animals were randomized to receive 5x106 CSCs labeled with PKH26 in PBS, 5x106 MSCs labeled with PKH26 in phosphate buffer solution (PBS) or PBS alone injection into the infarcted anterior ventricular free wall (10 rats for each group). [...]we examined Transforming growth factor-β1 (TGF-β1) as well as its downstream signaling molecules in left ventricular tissues.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2014.06.037