Detection of hypoxic areas in a syngeneic, orthotopic model of pancreatic ductal adenocarcinoma in mouse by in vivo imaging using photoacoustics

Hemoglobin concentration and relative tissue oxygen saturation/distribution were determined with an integrated photoacoustic(20Hz tunable laser 680-970nm)/ultrasound probe (LZ50 at 32 and 40 MHz) in combination with the Vevo®-LAZR software package. 1hr before sacrifice, mice were injected with pimon...

Full description

Saved in:
Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-05, Vol.13 (3), p.S19-S19
Main Authors: Heuchel, Rainer, Gerling, Marco, Zhao, Ying, Jose, Jithin, Norberg, Jessica, Toftgård, Rune, Löhr, Matthias
Format: Article
Language:English
Subjects:
Endocrinology & Metabolism
Gastroenterology and Hepatology
Medical research
Studies
Ultrasonic imaging
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hemoglobin concentration and relative tissue oxygen saturation/distribution were determined with an integrated photoacoustic(20Hz tunable laser 680-970nm)/ultrasound probe (LZ50 at 32 and 40 MHz) in combination with the Vevo®-LAZR software package. 1hr before sacrifice, mice were injected with pimonidazol to analyze formalin-fixed, paraffin-embedded tumor sections for hypoxic regions using hypoxiprobe kit.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2013.04.059