Independent, Reciprocal Neuromodulatory Control of Sweet and Bitter Taste Sensitivity during Starvation inDrosophila

An organism's behavioral decisions often depend upon the relative strength of appetitive and aversive sensory stimuli, the relative sensitivity to which can be modified by internal states like hunger. However, whether sensitivity to such opposing influences is modulated in a unidirectional or b...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2014-11, Vol.84 (4), p.806
Main Authors: Inagaki, Hidehiko K, Panse, Ketaki M, Anderson, David J
Format: Article
Language:English
Subjects:
Behavior
Food
Insects
Mammals
Nervous system
Neurons
Neuropeptides
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Summary:An organism's behavioral decisions often depend upon the relative strength of appetitive and aversive sensory stimuli, the relative sensitivity to which can be modified by internal states like hunger. However, whether sensitivity to such opposing influences is modulated in a unidirectional or bidirectional manner is not clear. Starved flies exhibit increased sugar and decreased bitter sensitivity. It is widely believed that only sugar sensitivity changes, and that this masks bitter sensitivity. Here we use gene- and circuit-level manipulations to show that sweet and bitter sensitivity are independently and reciprocally regulated by starvation inDrosophila. We identify orthogonal neuromodulatory cascades that oppositely control peripheral taste sensitivity for each modality. Moreover, these pathways are recruited at increasing hunger levels, such that low-risk changes (higher sugar sensitivity) precede high-risk changes (lower sensitivity to potentially toxic resources). In this way, state-intensity-dependent, reciprocal regulation of appetitive and aversive peripheral gustatory sensitivity permits flexible, adaptive feeding decisions.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2014.09.032