Up-Regulation of Cutaneous [alpha]1-Adrenoceptors in Complex Regional Pain Syndrome Type I

Background In a small radioligand-binding study of cutaneous [alpha]1-adrenoceptors in complex regional pain syndrome (CRPS), signal intensity was greater in the CRPS-affected limb than in controls. However, it was not possible to localize heightened expression of [alpha]1-adrenoceptors to nerves, s...

Full description

Saved in:
Bibliographic Details
Published in:Pain medicine (Malden, Mass.) Mass.), 2014-11, Vol.15 (11), p.1945
Main Authors: Finch, Philip M, Drummond, Eleanor S, Dawson, Linda F, Phillips, Jacqueline K, Drummond, Peter D
Format: Article
Language:English
Subjects:
Medical research
Pain
Wound healing
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background In a small radioligand-binding study of cutaneous [alpha]1-adrenoceptors in complex regional pain syndrome (CRPS), signal intensity was greater in the CRPS-affected limb than in controls. However, it was not possible to localize heightened expression of [alpha]1-adrenoceptors to nerves, sweat glands, blood vessels, or keratinocytes using this technique. Methods To explore this in the present study, skin biopsies were obtained from 31 patients with CRPS type I and 23 healthy controls of similar age and sex distribution. Expression of [alpha]1-adrenoceptors on keratinocytes and on dermal blood vessels, sweat glands, and nerves was assessed using immunohistochemistry. Results [alpha]1-Adrenoceptors were expressed more strongly in dermal nerve bundles and the epidermis both on the affected and contralateral unaffected side in patients than in controls (P
ISSN:1526-2375
1526-4637
DOI:10.1111/pme.12548