PKM2 contributes to cancer metabolism

Abstract Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer, less active dimer and active tetramer. While dimeric PKM2 diverts glucose metabolism towards anabolism through aer...

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Bibliographic Details
Published in:Cancer letters 2015-01, Vol.356 (2), p.184-191
Main Authors: Wong, Nicholas, Ojo, Diane, Yan, Judy, Tang, Damu
Format: Article
Language:English
Subjects:
Aerobic glycolysis
Biosynthesis
Breast cancer
Cancer metabolism
Carrier Proteins - biosynthesis
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell growth
Cell Proliferation
Cell signalling
Cell Transformation, Neoplastic - pathology
Enzymes
Epigenetics
Gene expression
Gene Expression Regulation, Neoplastic
Glucose - metabolism
Glycolysis - physiology
Head & neck cancer
Hematology, Oncology and Palliative Medicine
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Kinases
Liver cancer
Medical prognosis
Membrane Proteins - biosynthesis
Membrane Proteins - genetics
Membrane Proteins - metabolism
Metabolism
Musculoskeletal system
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neoplasms - metabolism
Neoplasms - pathology
PKM2
Proto-Oncogene Proteins c-myc - metabolism
Rodents
Thyroid cancer
Thyroid Hormone-Binding Proteins
Thyroid Hormones - biosynthesis
Thyroid Hormones - genetics
Thyroid Hormones - metabolism
Tumorigenesis
Tumors
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Summary:Abstract Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer, less active dimer and active tetramer. While dimeric PKM2 diverts glucose metabolism towards anabolism through aerobic glycolysis, tetrameric PKM2 promotes the flux of glucose-derived carbons for ATP production via oxidative phosphorylation. Equilibrium of the PKM2 dimers and tetramers is critical for tumorigenesis, and is controlled by multiple factors. The PKM2 dimer also promotes aerobic glycolysis by modulating transcriptional regulation. We will discuss the current understanding of PKM2 in regulating cancer metabolism.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.01.031