Combined Associations of Genetic and Environmental Risk Factors: Implications for Prevention of Breast Cancer

Genome-wide association studies (GWAS) have identified hundreds of genetic susceptibility loci for cancers and other complex diseases. However, the public health and clinical relevance of these discoveries is unclear. Evaluating the combined associations of genetic and environmental risk factors, pa...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2014-11, Vol.106 (11), p.1
Main Authors: Garcia-Closas, Montserrat, Gunsoy, Necdet Burak, Chatterjee, Nilanjan
Format: Article
Language:English
Subjects:
Breast cancer
Disease prevention
Environmental impact
Genetics
Risk factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 11
container_start_page 1
container_title JNCI : Journal of the National Cancer Institute
container_volume 106
creator Garcia-Closas, Montserrat
Gunsoy, Necdet Burak
Chatterjee, Nilanjan
description Genome-wide association studies (GWAS) have identified hundreds of genetic susceptibility loci for cancers and other complex diseases. However, the public health and clinical relevance of these discoveries is unclear. Evaluating the combined associations of genetic and environmental risk factors, particularly those that can be modified, will be critical in assessing the utility of genetic information for risk stratified prevention. In this commentary, using breast cancer as a model, we show that genetic information in combination with other risk factors can provide levels of risk stratification that could be useful for individual decision-making or population-based prevention programs. Our projections are theoretical and rely on a number of assumptions, including multiplicative models for the combined associations of the different risk factors, which need confirmation. Thus, analyses of epidemiological studies with high-quality risk factor information, as well as prevention trials, are needed to empirically assess the impact of genetics in risk stratified prevention.
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1639500979</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3534490071</sourcerecordid><originalsourceid>FETCH-proquest_journals_16395009793</originalsourceid><addsrcrecordid>eNqNTstqwzAQFCWFOmn_YSFng_yK495Sk7S9ldK7UZQ1KLV3Xa2c768C-YDMZRjmwTyoJCs3Os0zXS1UonVep9ttXT6ppchZRzR5maix5fHoCE-wE2HrTHBMAtzDOxIGZ8HQCfZ0cZ5pRApmgG8nv3AwNrCXV_gcp8HZW69nD18eLzEY9XXmzaORAK0hi_5ZPfZmEHy58UqtD_uf9iOdPP_NKKE78-wpWl22KZoqnqyb4r7UPwH8Sug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1639500979</pqid></control><display><type>article</type><title>Combined Associations of Genetic and Environmental Risk Factors: Implications for Prevention of Breast Cancer</title><source>Oxford Journals Online</source><creator>Garcia-Closas, Montserrat ; Gunsoy, Necdet Burak ; Chatterjee, Nilanjan</creator><creatorcontrib>Garcia-Closas, Montserrat ; Gunsoy, Necdet Burak ; Chatterjee, Nilanjan</creatorcontrib><description>Genome-wide association studies (GWAS) have identified hundreds of genetic susceptibility loci for cancers and other complex diseases. However, the public health and clinical relevance of these discoveries is unclear. Evaluating the combined associations of genetic and environmental risk factors, particularly those that can be modified, will be critical in assessing the utility of genetic information for risk stratified prevention. In this commentary, using breast cancer as a model, we show that genetic information in combination with other risk factors can provide levels of risk stratification that could be useful for individual decision-making or population-based prevention programs. Our projections are theoretical and rely on a number of assumptions, including multiplicative models for the combined associations of the different risk factors, which need confirmation. Thus, analyses of epidemiological studies with high-quality risk factor information, as well as prevention trials, are needed to empirically assess the impact of genetics in risk stratified prevention.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>CODEN: JNCIEQ</identifier><language>eng</language><publisher>Oxford: Oxford Publishing Limited (England)</publisher><subject>Breast cancer ; Disease prevention ; Environmental impact ; Genetics ; Risk factors</subject><ispartof>JNCI : Journal of the National Cancer Institute, 2014-11, Vol.106 (11), p.1</ispartof><rights>Copyright Oxford Publishing Limited(England) Nov 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Garcia-Closas, Montserrat</creatorcontrib><creatorcontrib>Gunsoy, Necdet Burak</creatorcontrib><creatorcontrib>Chatterjee, Nilanjan</creatorcontrib><title>Combined Associations of Genetic and Environmental Risk Factors: Implications for Prevention of Breast Cancer</title><title>JNCI : Journal of the National Cancer Institute</title><description>Genome-wide association studies (GWAS) have identified hundreds of genetic susceptibility loci for cancers and other complex diseases. However, the public health and clinical relevance of these discoveries is unclear. Evaluating the combined associations of genetic and environmental risk factors, particularly those that can be modified, will be critical in assessing the utility of genetic information for risk stratified prevention. In this commentary, using breast cancer as a model, we show that genetic information in combination with other risk factors can provide levels of risk stratification that could be useful for individual decision-making or population-based prevention programs. Our projections are theoretical and rely on a number of assumptions, including multiplicative models for the combined associations of the different risk factors, which need confirmation. Thus, analyses of epidemiological studies with high-quality risk factor information, as well as prevention trials, are needed to empirically assess the impact of genetics in risk stratified prevention.</description><subject>Breast cancer</subject><subject>Disease prevention</subject><subject>Environmental impact</subject><subject>Genetics</subject><subject>Risk factors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNTstqwzAQFCWFOmn_YSFng_yK495Sk7S9ldK7UZQ1KLV3Xa2c768C-YDMZRjmwTyoJCs3Os0zXS1UonVep9ttXT6ppchZRzR5maix5fHoCE-wE2HrTHBMAtzDOxIGZ8HQCfZ0cZ5pRApmgG8nv3AwNrCXV_gcp8HZW69nD18eLzEY9XXmzaORAK0hi_5ZPfZmEHy58UqtD_uf9iOdPP_NKKE78-wpWl22KZoqnqyb4r7UPwH8Sug</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Garcia-Closas, Montserrat</creator><creator>Gunsoy, Necdet Burak</creator><creator>Chatterjee, Nilanjan</creator><general>Oxford Publishing Limited (England)</general><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20141101</creationdate><title>Combined Associations of Genetic and Environmental Risk Factors: Implications for Prevention of Breast Cancer</title><author>Garcia-Closas, Montserrat ; Gunsoy, Necdet Burak ; Chatterjee, Nilanjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_16395009793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Breast cancer</topic><topic>Disease prevention</topic><topic>Environmental impact</topic><topic>Genetics</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Closas, Montserrat</creatorcontrib><creatorcontrib>Gunsoy, Necdet Burak</creatorcontrib><creatorcontrib>Chatterjee, Nilanjan</creatorcontrib><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Closas, Montserrat</au><au>Gunsoy, Necdet Burak</au><au>Chatterjee, Nilanjan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined Associations of Genetic and Environmental Risk Factors: Implications for Prevention of Breast Cancer</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><date>2014-11-01</date><risdate>2014</risdate><volume>106</volume><issue>11</issue><spage>1</spage><pages>1-</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><coden>JNCIEQ</coden><abstract>Genome-wide association studies (GWAS) have identified hundreds of genetic susceptibility loci for cancers and other complex diseases. However, the public health and clinical relevance of these discoveries is unclear. Evaluating the combined associations of genetic and environmental risk factors, particularly those that can be modified, will be critical in assessing the utility of genetic information for risk stratified prevention. In this commentary, using breast cancer as a model, we show that genetic information in combination with other risk factors can provide levels of risk stratification that could be useful for individual decision-making or population-based prevention programs. Our projections are theoretical and rely on a number of assumptions, including multiplicative models for the combined associations of the different risk factors, which need confirmation. Thus, analyses of epidemiological studies with high-quality risk factor information, as well as prevention trials, are needed to empirically assess the impact of genetics in risk stratified prevention.</abstract><cop>Oxford</cop><pub>Oxford Publishing Limited (England)</pub></addata></record>
fulltext fulltext
identifier ISSN: 0027-8874
ispartof JNCI : Journal of the National Cancer Institute, 2014-11, Vol.106 (11), p.1
issn 0027-8874
1460-2105
language eng
recordid cdi_proquest_journals_1639500979
source Oxford Journals Online
subjects Breast cancer
Disease prevention
Environmental impact
Genetics
Risk factors
title Combined Associations of Genetic and Environmental Risk Factors: Implications for Prevention of Breast Cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T19%3A19%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20Associations%20of%20Genetic%20and%20Environmental%20Risk%20Factors:%20Implications%20for%20Prevention%20of%20Breast%20Cancer&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=Garcia-Closas,%20Montserrat&rft.date=2014-11-01&rft.volume=106&rft.issue=11&rft.spage=1&rft.pages=1-&rft.issn=0027-8874&rft.eissn=1460-2105&rft.coden=JNCIEQ&rft_id=info:doi/&rft_dat=%3Cproquest%3E3534490071%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_16395009793%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1639500979&rft_id=info:pmid/&rfr_iscdi=true