Study on the Toxicology of PM10 in Manas River Basin of China

PM10 samples were collected in spring and summer 2010 in Manas River Basin, Xinjiang, China. The water-soluble fraction was subjected to plasmid DNA assay, and several conclusions were obtained. Damages to DNA caused by PM10 with the same mass concentration were different and related to the source o...

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Bibliographic Details
Published in:Nature environment and pollution technology 2014-12, Vol.13 (4), p.731
Main Authors: Yuejian, Wang, Junmin, Zhang, lin, Liu, Jianlong, Zhang, Alexander, Solvakoru
Format: Article
Language:English
Subjects:
Chemical bonds
DNA damage
Free radicals
Hypotheses
Plasmids
Toxicity
Toxicology
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Summary:PM10 samples were collected in spring and summer 2010 in Manas River Basin, Xinjiang, China. The water-soluble fraction was subjected to plasmid DNA assay, and several conclusions were obtained. Damages to DNA caused by PM10 with the same mass concentration were different and related to the source of particulate matters and their complex components. The correlation between mass concentration and damage rates of the samples was not linear, indicating that the rate of particulate matter damage reached a threshold value under the synthetic action of their complex components, and then the range of damage changed with increased mass concentration. Damage to DNA caused by PM10 samples in spring was significantly lower than that in summer. Little difference in toxicity was observed between whole samples and their water-soluble fractions in both spring and summer. In other words, in the same city and under similar weather conditions, the toxicity of the whole particulate matter samples was close to the toxicity of their water-soluble fraction, indicating that the damage to DNA was usually due to the water-soluble fraction of particulate matters.
ISSN:0972-6268
2395-3454