Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles

Abstract High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed to determine the radiosensitizing potential of PEGylated nanogel containing gold nanoparticles (GNG) and the cellular mechanism involved. GNG pretreatme...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2014-05, Vol.347 (1), p.151-158
Main Authors: Yasui, Hironobu, Takeuchi, Ryo, Nagane, Masaki, Meike, Shunsuke, Nakamura, Yoshinari, Yamamori, Tohru, Ikenaka, Yoshinori, Kon, Yasuhiro, Murotani, Hiroki, Oishi, Motoi, Nagasaki, Yukio, Inanami, Osamu
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Aqueous solutions
Cancer
Cell cycle
Cell Line, Tumor
Cricetinae
Cricetulus
Deoxyribonucleic acid
DNA
DNA repair
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Endoplasmic reticulum stress
Gels
Gold
Gold - chemistry
Gold nanoparticle
Hematology, Oncology and Palliative Medicine
Hypoxia
Melanoma
Metal Nanoparticles
Mice
Nanoparticles
Phase transitions
Polyethylene glycol
Polyethylene Glycols - chemistry
Proteins
Radiation
Radiation-Sensitizing Agents - pharmacology
Studies
Tumors
X-Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed to determine the radiosensitizing potential of PEGylated nanogel containing gold nanoparticles (GNG) and the cellular mechanism involved. GNG pretreatment increased the levels of reproductive cell death and apoptosis induced by X-irradiation. GNG accumulated in cytoplasm and increased the expression of endoplasmic reticulum (ER) stress-related protein. GNG suppressed the repair capacity of DNA after X-irradiation by down-regulating DNA repair-related proteins. Our results suggest that GNG radiosensitized cells by enhancing apoptosis and impairing DNA repair capacity via ER stress induction.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.02.005