Curcumin: A pleiotropic phytonutrient in diabetic complications

Abstract Curcumin is the major polyphenolic constituent of an indigenous herb, Curcuma longa, found to have a wide range of applications right from its kitchen use as a spicy ingredient to therapeutic and medicinal applications in various diseases. Curcumin has been identified to have a plethora of...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-02, Vol.31 (2), p.276-282
Main Authors: Jeenger, Manish Kumar, M.S.(Pharm.), Shrivastava, Shweta, M.S.(Pharm.), Yerra, Veera Ganesh, M.S.(Pharm.), Naidu, V.G.M., Ph.D, Ramakrishna, Sistla, Ph.D, Kumar, Ashutosh, Ph.D
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Curcumin
Curcumin - pharmacology
Cytokines
Diabetes Complications - drug therapy
Diabetic complications
Disease Models, Animal
Gastroenterology and Hepatology
Humans
Inflammation - drug therapy
Kinases
Nephropathy
Neuropathy
Nitric oxide
Phytochemicals - pharmacology
Retinopathy
Rodents
Spices
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Summary:Abstract Curcumin is the major polyphenolic constituent of an indigenous herb, Curcuma longa, found to have a wide range of applications right from its kitchen use as a spicy ingredient to therapeutic and medicinal applications in various diseases. Curcumin has been identified to have a plethora of biologic and pharmacologic properties owing to its antioxidant and anti-inflammatory activities. This pleiotropic regulation of redox balance of cell and inflammation might be the basis of curcumin's beneficial activities in various pathologic conditions including diabetic complications. This review summarizes various in vitro, in vivo studies done on curcumin and its therapeutic utility in diabetic micro-vascular complications. This review also emphasizes the importance of curcumin in addition to the existing therapeutic modalities in diabetic complications.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2014.06.015