Enrichment of the rare CD4+[gamma][delta] T-cell subset in patients with atypical CD3[delta] deficiency

[...]atypical CD3δ deficiency leading to reduced surface TCR expression showed preserved γδ, but not β, T-cell numbers with overrepresentation of CD4+ γδ T cells, supporting low TCR-dependence for positive selection of CD4- γδ T cells and disrupted negative selection of CD4+ γδ T cells....

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2014-04, Vol.133 (4), p.1205
Main Authors: Garcillán, Beatriz, Mazariegos, Marina S, Fisch, Paul, Res, Pieter C, Muñoz-Ruiz, Miguel, Gil, Juana, López-Granados, Eduardo, Fernández-Malavé, Edgar, Regueiro, José R
Format: Article
Language:English
Subjects:
Lymphocytes
Mutation
Patients
Rodents
T cell receptors
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Summary:[...]atypical CD3δ deficiency leading to reduced surface TCR expression showed preserved γδ, but not β, T-cell numbers with overrepresentation of CD4+ γδ T cells, supporting low TCR-dependence for positive selection of CD4- γδ T cells and disrupted negative selection of CD4+ γδ T cells.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2013.10.002