A nutrigenetics proof-of-principle study: 12 years of molecular genetics meets 70 years of nutrition science

The 3 y that preceded the publication were focused on one goal: developing a botanical supplement that preferentially lowers specific inflammatory mediators that are overexpressed in some healthy individuals due to the function of specific single-nucleotide polymorphisms (SNPs) in the IL-1 genes. In...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2009-03, Vol.25 (3), p.258-260
Main Authors: Randolph, Keith, Ph.D, Kornman, Kenneth, Ph.D
Format: Article
Language:English
Subjects:
Chronic illnesses
Gastroenterology and Hepatology
Genes
Genetics
Genotypes
Health risks
Nutrigenomics
Studies
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Summary:The 3 y that preceded the publication were focused on one goal: developing a botanical supplement that preferentially lowers specific inflammatory mediators that are overexpressed in some healthy individuals due to the function of specific single-nucleotide polymorphisms (SNPs) in the IL-1 genes. In clinical samples on large numbers of subjects, the same genotypes responsible for IL-1β overexpression were also associated with higher tissue levels of IL-1β, higher C-reactive protein, and increased risk for cardiovascular.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2008.10.005