Molecular mechanism underlying acute pancreatitis-induced autophagy

[...]we found that the novel VMP1-Beclin1-hVps34 complex favors the recruitment of ATG16L and topologically links two steps of the autophagy core molecular machinery, named the Class III PI3K and the ATG16L-LC3 lipidation systems.

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-03, Vol.13 (2), p.e56-e56
Main Authors: Molejon, M.I, Ropolo, A, Boggio, V, Valenzuela, G, Rittaco, T, Vaccaro, M.I
Format: Article
Language:English
Subjects:
Autophagy
Endocrinology & Metabolism
Gastroenterology and Hepatology
Medical research
Pancreas
Online Access:Get full text
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Description
Summary:[...]we found that the novel VMP1-Beclin1-hVps34 complex favors the recruitment of ATG16L and topologically links two steps of the autophagy core molecular machinery, named the Class III PI3K and the ATG16L-LC3 lipidation systems.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2012.12.252