Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction

• Published in: The American heart journal 2013, Vol.165 (1), p.26-33.e3
• Main Authors: Martin, Seth S., MD, Gosch, Kensey, MS, Kulkarni, Krishnaji R., PhD, Spertus, John A., MD, MPH, Mathews, Robin, MD, Ho, P. Michael, MD, Maddox, Thomas M., MD, MSc, Newby, L. Kristin, MD, MSc, Alexander, Karen P., MD, Wang, Tracy Y., MD, MHS, MSc
• Format: Article
• Language: English
• Subjects: Aged; Cardiovascular; Cardiovascular disease; Cholesterol; Cholesterol, LDL - blood; Cholesterol, LDL - drug effects; Cohort Studies; Female; Follow-Up Studies; Heart attacks; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypercholesterolemia - drug therapy; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - drug therapy; Prospective Studies; Risk Factors; Studies; Treatment Failure; Treatment Outcome
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/j.ahj.2012.10.005

Background Although controversial, reducing low-density lipoprotein cholesterol (LDL-C) to target levels remains a common therapeutic goal after acute myocardial infarction (AMI). We sought to illuminate patient and provider characteristics associated with LDL-C goal nonattainment after AMI. Methods In an observational registry of 24 US hospitals, we included 366 patients with AMI who had baseline LDL-C levels ≥100 mg/dL and underwent 6-month fasting LDL-C reassessment. Our primary outcome was failure to reach the guideline-recommended LDL-C goal of