The Th1 life cycle: molecular control of IFN-[gamma] to IL-10 switching

Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces "intrinsic" IL-10 expressio...

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Bibliographic Details
Published in:Trends in immunology 2011-06, Vol.32 (6), p.278
Main Authors: Cope, Andrew, Le Friec, Gaelle, Cardone, John, Kemper, Claudia
Format: Article
Language:English
Subjects:
Antigens
Biomedical research
Cytokines
Cytotoxicity
Disease
Hospitals
Immune system
Inflammatory bowel disease
Inflammatory diseases
Lymphocytes
Medical research
Mortality
Regulation
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Summary:Control of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces "intrinsic" IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2011.03.010