Intraocular pressure profile of a child on a systemic corticosteroid

To report the ocular hypertensive response to high-dose systemic corticosteroid in a pediatric patient. Observational case report. A 9-year-old patient with leukemia received oral prednisolone at a dosage of 2.3 mg/kg/d for 5 weeks, followed by a 4-month break and then a 4-week course of oral dexame...

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Bibliographic Details
Published in:American journal of ophthalmology 2004, Vol.137 (1), p.198-201
Main Authors: Tham, Clement C.Y., Ng, Joan S.K., Li, Randa T.H., Chik, Ki Wai, Lam, Dennis S.C.
Format: Article
Language:English
Subjects:
Administration, Oral
Biological and medical sciences
Child
Eye
Female
Glaucoma
Glucocorticoids - administration & dosage
Glucocorticoids - adverse effects
Humans
Hypertension
Intraocular Pressure - drug effects
Medical sciences
Medical treatment
Ocular Hypertension - chemically induced
Ocular Hypertension - physiopathology
Pharmacology. Drug treatments
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Prednisolone - administration & dosage
Prednisolone - adverse effects
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Summary:To report the ocular hypertensive response to high-dose systemic corticosteroid in a pediatric patient. Observational case report. A 9-year-old patient with leukemia received oral prednisolone at a dosage of 2.3 mg/kg/d for 5 weeks, followed by a 4-month break and then a 4-week course of oral dexamethasone at 10 mg/d. Detailed ocular examination was performed for both eyes before and regularly throughout the two courses of treatment. The intraocular pressure in both eyes rose to almost 40 mm Hg after only 8 days of oral corticosteroid. On stopping systemic corticosteroid, the intraocular pressure rapidly returned to baseline level within 2 days. A similar intraocular pressure profile was recorded for both eyes during the course of oral dexamethasone. The patient remained largely asymptomatic throughout. Systemic corticosteroid may give rise to significant but asymptomatic ocular hypertension in pediatric patients.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(03)00838-9