Conjunctival hyperemia associated with bimatoprost use: A histopathologic study

To evaluate histopathologic signs of conjunctival inflammation in patients with conjunctival hyperemia induced by bimatoprost treatment. Prospective interventional study. The study included 15 eyes of 15 patients scheduled for cataract surgery. Patients in the treatment group (n = 9) exhibited trace...

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Bibliographic Details
Published in:American journal of ophthalmology 2004-08, Vol.138 (2), p.310-313
Main Authors: Leal, Bruno C., Medeiros, Felipe A., Medeiros, Fabrício W., Santo, Ruth M., Susanna, Remo
Format: Article
Language:English
Subjects:
Amides
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
Bimatoprost
Biological and medical sciences
Biopsy
Cataract Extraction
Cataracts
Cloprostenol - analogs & derivatives
Conjunctiva - blood supply
Conjunctiva - pathology
Conjunctivitis - chemically induced
Conjunctivitis - pathology
Drug toxicity and drugs side effects treatment
Eye surgery
Glaucoma, Open-Angle - drug therapy
Humans
Hyperemia - chemically induced
Hyperemia - pathology
Intraocular Pressure - drug effects
Lipids - adverse effects
Lipids - therapeutic use
Medical sciences
Patients
Pharmacology. Drug treatments
Prospective Studies
Surgery
Toxicity: eye
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Summary:To evaluate histopathologic signs of conjunctival inflammation in patients with conjunctival hyperemia induced by bimatoprost treatment. Prospective interventional study. The study included 15 eyes of 15 patients scheduled for cataract surgery. Patients in the treatment group (n = 9) exhibited trace to moderate conjunctival hyperemia when treated with bimatoprost 0.03% every day for 15 to 30 days before surgery. The control group (n = 6) included untreated patients with no ocular disease other than cataract. Conjunctival biopsies were obtained for histologic evaluation with light microscopy. Vascular congestion was observed in biopsies from 7 patients (78%) in the bimatoprost group and 5 patients (83%) in the control group. Signs of inflammation were found in biopsies from 2 patients (22%) in the bimatoprost group and 2 patients (33%) in the control group. Histopathologic signs of inflammation were no more frequent in conjunctival specimens from bimatoprost-treated patients with trace to moderate hyperemia than in those from untreated control subjects.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2004.03.006