Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1[alpha]

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related with chemoresistance of solid tumors. The purpose of this study was to investigate the ability of noscapine to inhibit HIF-1α and sensitize ovarian cancer cells to cisplatin (DDP) under hypoxic conditions. Herein, we report that noscapine...

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Bibliographic Details
Published in:Cancer letters 2011-06, Vol.305 (1), p.94
Main Authors: Su, Wenjing, Huang, Lei, Ao, Qilin, Zhang, Qinghua, Tian, Xun, Fang, Yong, Lu, Yunping
Format: Article
Language:English
Subjects:
Apoptosis
Cancer therapies
Cell cycle
Clinical trials
Genes
Hypoxia
Ovarian cancer
Proteins
Statistical analysis
Tumors
Vascular endothelial growth factor
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Summary:Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related with chemoresistance of solid tumors. The purpose of this study was to investigate the ability of noscapine to inhibit HIF-1α and sensitize ovarian cancer cells to cisplatin (DDP) under hypoxic conditions. Herein, we report that noscapine sensitized cobalt-induced chemoresistant ovarian cancer cells to DDP-induced apoptosis and inhibition of cell proliferation. Noscapine also promoted proteasome-mediated degradation of cobalt-stabilized HIF-1α protein, with subsequent inhibition of HIF-1 transcriptional activity. These data establish noscapine as a small molecule inhibitor of HIF-1α and provide an evidence for its combination with DDP in combating ovarian cancer chemoresistance.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.02.031